Developmental Origin of Fat: Tracking Obesity to Its Source
@article{Gesta2007DevelopmentalOO, title={Developmental Origin of Fat: Tracking Obesity to Its Source}, author={Stéphane Gesta and Yu-Hua Tseng and Ronald Kahn and Angiotensinogen and Peter K Jackson and Peter K Jackson}, journal={Cell}, year={2007}, volume={131}, pages={242-256}, url={https://api.semanticscholar.org/CorpusID:52808888} }1,502 Citations
Brown adipose tissue: development, metabolism and beyond.
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The present review integrates the recent advancements on the regulation of brown fat formation and activity by developmental and hormonal signals in relation to its metabolic function to suggest a potential target for the treatment of obesity and metabolic syndrome.
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This review highlights the mechanisms of fatty acid uptake, trafficking and oxidation in brown fat thermogenesis and focuses on BAT's morphological and functional characteristics and fatty acid synthesis, storage, oxidation and use as a source of energy.
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Altogether, the existing literature suggests that unsaturated fat has more benign effects on adipose tissue distribution when compared to long-chain saturated fat, however, the mechanisms of action remain poorly characterised.
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The role of BAT in total energy expenditure, as well as lipid and glucose homeostasis, and to discuss new possible activators of brown adipose tissue in humans to treat obesity and metabolic disorders are explored.
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It is argued that efforts to prevent obesity-related cardiometabolic disease should focus on anti-obesogenic strategies to restore normal adipose tissue metabolism.
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An overview of recent advances in understanding white fat browning and the role of BAT in lipid metabolism is provided.
Mechanisms of obesity and related pathologies: Transcriptional control of adipose tissue development
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A discussion of the recent identification of molecular mechanisms controlling the development and function of adipose tissues, as well as how these mechanisms contribute to the regulation of energy balance in mammals is focused on.
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