Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • NEWS

Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’

Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.
By
  1. Miryam Naddaf
  2. Elizabeth Gibney

This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Nature 646, 521-522 (2025)

doi: https://doi.org/10.1038/d41586-025-03193-3

Additional reporting by Katie Kavanagh.

References

  1. Conrad, N. et al. Lancet 401, 1878–1890 (2023).

    Article  PubMed  Google Scholar 

  2. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. J. Immunol 155, 1151–1164 (1995).

    Article  PubMed  Google Scholar 

  3. Brunkow, M. E. et al. Nature Genet. 27, 68–73 (2001).

    Article  PubMed  Google Scholar 

  4. Wildin, R. S. et al. Nature Genet. 27, 18–20 (2001).

    Article  PubMed  Google Scholar 

  5. Hori, S., Nomura, T. & Sakaguchi, S. Science 299, 1057–1061 (2003).

    Article  PubMed  Google Scholar 

Download references

Subjects

Latest on:

Nature Careers

Jobs

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing

Search

Advanced search

Quick links