Scripps Research Digital Trials Center

🚨 New paper from the Scripps Research Digital Trials Center team! 👇

What if we could predict diabetes risk years before a diagnosis? The PROGRESS study, led by Scripps Research Digital Trials Center, shows it’s possible. Recently featured on NBC 7 and published in Nature Medicine, PROGRESS combined continuous glucose monitoring, wearable sensors, biosamples, and EHR data to create an AI model that uncover hidden metabolic risk — even when standard lab results, like HbA1c, appear normal. In this interview, Dr. Jay Pandit shares how these findings could transform prevention, giving people a window to act before disease takes hold. Watch the interview: https://lnkd.in/g_F_-2EU We’ll share the Nature Medicine paper link in the comments for those who want to dive deeper into the methods and results. #DiabetesPrevention #MetabolicHealth #NatureMedicine #DigitalMedicine #ScrippsResearch

Advancing our understanding of metabolic health beyond HbA1c A new Nature Medicine publication from the Scripps Research Digital Trials Center reveals how AI and multimodal data can uncover hidden signals of diabetes risk—well before standard lab values tell the full story. The PROGRESS study (PRediction Of Glycemic RESponse Study), a fully decentralized clinical trial enrolling over 1,000 participants nationwide, used continuous glucose monitors, EHR data, genetic-based risk scores, microbiome profiles, physical activity, and diet tracking to build an AI model that captured subtle metabolic shifts missed by traditional diagnostics. What stood out: • Two individuals with identical HbA1c values can have strikingly different glucose dynamics • Time to glucose recovery is a strong early marker of elevated risk • A diverse gut microbiome and higher physical activity levels correlate with improved glucose control • Resting heart rate and postprandial glucose spikes provide actionable signals of disease trajectory This study marks a significant advance in how we detect and characterize pre-diabetes and type 2 diabetes risk—moving toward a more granular, dynamic, and personalized approach to metabolic health. It also demonstrates what’s possible when clinical trials are reimagined: remote, participant-driven, and deeply data-rich. We're especially grateful to the PROGRESS study participants whose time, commitment, and contributions made this research possible. Read the paper: https://lnkd.in/gytuq-nv Learn more about Scripps Digital Trials Center: https://lnkd.in/g2An-xiY Authors include: Ed Ramos, Giorgio Quer, Mattia Carletti, Jay Pandit, Matteo Gadaleta, Danielle Chiang (Jones), Felipe D., Katie Quartuccio, Brianna Fernandez, Juan Antonio Raygoza Garay, Ali Torkamani, Katie Baca-Motes, and Eric Topol, MD of Scripps Research; Riccardo Miotto (Tempus AI); Hagai Rossman (Pheno.AI); Vik Kheterpal and Benjamin Berk MD (CareEvolution); and Eran Segal (Weizmann Institute of Science) #MetabolicHealth #DiabetesResearch #AIinMedicine #DigitalTrials #PrecisionMedicine #NatureMedicine #Wearables #RealWorldData #ScrippsResearch #PROGRESSstudy

🧠 Today is World Brain Day, a reminder of how much we still have to learn about the brain, and how digital health research is accelerating that understanding. At the Scripps Research Digital Trials Center , we’re using wearable sensors, real-world data, and remote cognitive testing to better understand how sleep, memory, and brain function are connected. One example is #REFRESH-NOW, a study exploring how changes in sleep patterns may signal early shifts in brain health. By collecting data from participants in real-world settings, we’re opening up new opportunities to detect changes earlier and design more personalized interventions. 📽️ Learn more about REFRESH-NOW and the future of brain health research: https://lnkd.in/gVgcJDPF #WorldBrainDay #BrainHealth #DigitalHealth #SleepScience #RealWorldData #ScrippsResearch

PowerMom: A New Model for Inclusive, Digital Maternal Health Research Our new Scripps Research Digital Trials Center publication in JMIR Formative Research highlights the #PowerMom study, a digital health platform designed to engage pregnant and postpartum individuals across all 50 states, Puerto Rico, and Guam. More than 5,600 participants enrolled, many from communities historically underrepresented in research. Through surveys, wearables, and optional electronic health record sharing, we captured over 378,000 biometric data points to build a more continuous, real-world view of pregnancy. The PowerMom study underscores the potential of digital health to bridge gaps in women’s health research. By engaging a broad and diverse population, it takes a meaningful step toward equity in maternal health. Key lessons:  • Remote recruitment can work—but trust, tech access, and cultural relevance matter • Sustained engagement requires thoughtful design and community input • Real-world data from wearables and EHRs can complement traditional clinical insights PowerMom offers a scalable, patient-centered framework for the future of maternal health research—one that reflects and respects the communities it serves. Read the paper: https://lnkd.in/g2VTgKGh Learn more about the PowerMom consortium: https://lnkd.in/gbdW2av3 #MaternalHealth #DigitalHealth #WomensHealth #DecentralizedTrials #ClinicalResearch #HealthEquity #ScrippsResearch

What if the future of aging isn’t just about living longer—but living better? In the next Front Row lecture from Scripps Research, Dr. Eric Topol will explore the science behind longer, healthier lives. Drawing from his new book on longevity, Dr. Topol will highlight how breakthroughs in AI, drug discovery, and precision medicine are reshaping how we approach chronic conditions like cancer, diabetes, and neurodegeneration. It’s a conversation about more than medicine—it’s about the promise of healthspan, not just lifespan. For those working at the intersection of research, technology, and human health, this talk is not to be missed. 📅 Wednesday, May 21, 2025 📍 Free and open to all 🔗 Register here: https://lnkd.in/gRuhrk88 #Longevity #PrecisionMedicine #AIinHealth #DigitalHealth #EricTopol #ScrippsResearch #FrontRow

💡 What if clinical trials were designed around the people who need them most? In this new Q&A, Ed Ramos, Director of the Scripps Research Digital Trials Center, shares the vision driving his team’s work: rethinking clinical trial infrastructure to put participants at the center, reduce burden, and bring more meaning to the research experience. From exploring sleep as a tool to improve blood sugar control to leveraging wearables for early detection of illness, the work from Ed and his team sits at the intersection of innovation and empathy. He also opens up about a new focus area: women’s health—where his team is investigating how physiological changes around menopause may be linked to disease onset such as Alzheimer’s disease. What stands out most is his approach: • Prioritizing access, transparency, and value in study design • Applying digital health tools to real-world questions • Listening as the foundation of both mentorship and community engagement Worth a read for anyone reimagining research with people at the center. Read the full interview: https://lnkd.in/gGGv26RM #DigitalHealth #ClinicalResearch #WomensHealth #ParticipantCenteredResearch #AlzheimersResearch #ScrippsResearch #HealthEquity

🎉 Celebrating a milestone: Our first spin-out from Scripps Research Digital Trials Center 🎉 At Scripps Research Digital Trials Center, we’ve spent years pioneering new models for decentralized clinical trials, real-world data collection, and participant-centered research. Our mission has always been to push the boundaries of what’s possible in clinical trials—making research more accessible, scalable, and inclusive. Today, we’re thrilled to share an exciting milestone: the launch of GSD Health Research, the first spin-out from the Digital Trials Center (DTC). Co-founded by Katie Baca-Motes and Ed Ramos, both of whom played instrumental roles in building the DTC, GSD Health Research (Generational Science & Discovery) is a NextGen CRO dedicated to advancing women’s health research. This is exactly the kind of impact we envisioned when we set out to reimagine clinical trials. The launch of GSD Health Research demonstrates how research innovation can scale—creating new opportunities to accelerate discovery in women’s health and beyond. While Ed Ramos continues to lead the Scripps Research Digital Trials Center and Katie Baca-Motes remains on as a strategic advisor, this next step is about expanding what we’ve built together—bridging academic research with industry solutions to drive even greater impact. We couldn’t be more excited to see where this journey leads and to continue collaborating across both organizations. Congratulations to the GSD Health Research team—we’re proud to see this next chapter begin! #ClinicalResearch #WomensHealth #DigitalTrials #Innovation #ScrippsResearch #GSDHealthResearch