I am considering the set $S'$, which extends the original problem to allow non-negative integer exponents: $$ S'=\{(x,y,z)\in \mathbb{R}^3:\exists n_1,n_2,n_3\in\mathbb{N}_{\ge 0},\ x^{n_1}+y^{n_2}=z^{n_3}\} $$ (with the standard convention that $0^0$ is undefined).
Is the complement of the closure, $(\overline{S'})^c$, exactly equal to the following set?
$$ \{(x,y,z) \in \mathbb{R}^3 : |z|<1 \text{ and } ( (x > 1 \text{ and } y > 0) \text{ or } (y > 1 \text{ and } x > 0) ) \} $$
This region excludes the "mixed sign" or "negative/negative" areas where subtraction of powers allows the equation to be solved.